Synthesis, Characterization, and Anti-Cancer Activity of Some New N'-(2-Oxoindolin-3-ylidene)-2-propylpentane hydrazide-hydrazones Derivatives

El-Faham, Ayman; Farooq, Muhammad; Khattab, Sherine N.; Abutaha, Nael; Wadaan, Mohammad A.; Ghabbour, Hazem A.; Fun, Hoong-Kun

In the crystal packing (Figure 4 ), the molecules are linked by intermolecular C17A-H17B···Br1B, C17B-H17D···O2B and C18A-H18B···O2A hydrogen bonds ( Table 2) into two-dimensional networks parallel to the bc plane ( Figure 4 and Table 2 ). The asymmetric unit contains two molecules of the compound with disorder in one of the ethylene arms. The molecular structure of compound 4g is composed of a 2-oxoindoline ring (C1/N1/C2-C8) which is linked with two side chains at N1 and C8. The two molecules in the asymmetric unit are with Z configuration about the C8=N2 double bond ( Figure 3 ). The Z configuration of 4a is stabilized with intramolecular hydrogen N3-H3N···O2 ( Table 2 ). The single bond N2-N3 is clearly characterized by the distances of 1.355 (3) Å and 1.361 (4) Å, respectively, for molecules A and B. The double bond of C8=N2 is characterized by the distances of 1.298 (3) Å and 1.283 (4) Å, for molecules A and B, respectively. A B Figure 3 . ORTEP diagram of the asymmetric unit consisting of two symmetry-independent molecules. The ellipsoids are drawn at the 50% probability level with hydrogen atoms being shown as spheres of arbitrary radii. One of the molecules has disorder in the side chain C11B-C13B. (3) 149.00 C17B−H17D···O2B ii 0.9700 2.4100 3.139 (4) 131.00 C18A−H18B···O2A iii 0.9700 2.2900 3.096 (3) 140.00