Synthesis, Characterization, Crystal Structure and Antimicrobial Activity of Copper(II) Complexes with the Schiff Base Derived from 2-Hydroxy-4-Methoxybenzaldehyde

Pahon?u, Elena; Ilie?, Diana-Carolina; Shova, Sergiu; Paraschivescu, Codru?a; Badea, Mihaela; Gulea, Aurelian; Ro?u, Tudor

The synthesis of new compounds that are used for the treatment of infections with less secondary effects is a biomedical problem [1, 2] . Recently research has focused increasingly on the synthesis of transition metal complexes with Schiff-type ligands, due to the biological properties that they present. Many compounds derived from Schiff bases exhibit antibacterial, antifungal, antitumor and anti-HIV activities [3] [4] [5] [6] [7] [8] [9] [10] [11] [12] [13] [14] . Schiff bases derived from salicylaldehyde represent an important class of ligands due to their ability to be used in various fields [15] [16] [17] [18] [19] . Having a high capacity chelating and redox potential the positive Cu 2+ ion is biologically active, and participates in many processes in the body [20] [21] [22] . Copper complexes are also among the most potent antiviral, antitumor and anti-inflammatory agents [23] . In addition, it was found that most of benzocaine-containing compounds are biologically active. Recent research has demonstrated that, these derivatives exhibit antimicrobial activity against different species [24] [25] [26] . Based on these observations and considering research in this area in the present study, we report the synthesis, characterization, antimicrobial studies of some copper(II) complexes containing a Schiff base ligand derived from 2-hydroxy-4-methoxybenzaldehyde and ethyl-4-aminobenzoate, with a special impetus on ligand structural investigations. The crystal structures of ligand and complex 6 were studied by X-ray diffraction. The biological properties of these compounds was tested for their antibacterial and antifungal activities against Escherichia coli ATCC 25922, Salmonella enteritidis, Staphylococcus aureus ATCC 25923 and Candida albicans strains.