The Glycoproteins of All Filovirus Species Use the Same Host Factors for Entry into Bat and Human Cells but Entry Efficiency Is Species Dependent

Hoffmann, Markus; González Hernández, Mariana; Berger, Elisabeth; Marzi, Andrea; Pöhlmann, Stefan

The family of Filoviridae contains three genera, Ebolavirus, Marburgvirus and Cuevavirus. The only species within the Marburgvirus genus, Marburg marburgvirus (members: Marburg virus, MARV and Ravn virus, RAVV), and the following ebolaviruses are pathogenic to humans: Ebola virus (EBOV, species Zaire ebolavirus), Sudan virus (SUDV, species Sudan ebolavirus, Bundibugyo virus (BDBV, species Bundibugyo ebolavirus) and Taï Forest virus, (TAFV, species Taï Forest ebolavirus). Reston virus (RESTV), the only member of the fifth ebolavirus species, causes disease in NHP but has so far not been associated with disease in humans. Moreover, RESTV infection of pigs and bats has been documented [1, 2] . The genome of Lloviu virus (LLOV), the only virus within the species Lloviu cuevavirus, genus Cuevavirus, has been detected in dead bats (Miniopteris schreibersii) in Northern Spain [3] , its potential to infect humans is unknown.