Selected article for: "bat cell and filovirus gps"
Author: Hoffmann, Markus; González Hernández, Mariana; Berger, Elisabeth; Marzi, Andrea; Pöhlmann, Stefan
Title: The Glycoproteins of All Filovirus Species Use the Same Host Factors for Entry into Bat and Human Cells but Entry Efficiency Is Species Dependent
  • Document date: 2016_2_22
    • ID: 146cwh6y_31
    Snippet: LLOV-GP mediated highly efficient entry into three out of four fruit bat cell lines (HypNi/ 1.1, EidNi/41, EpoNi/22.1), in line with a previous study reporting superior transduction efficiency by LLOV-GP (relative to EBOV-, RESTV-and MARV-GP) when bat cell lines were examined [50] . In addition, we were able to confirm previous data that indicated reduced transduction of NHP cells by EBOV2014-GP compared to EBOV1976-GP [47] . This observation is .....
    Document: LLOV-GP mediated highly efficient entry into three out of four fruit bat cell lines (HypNi/ 1.1, EidNi/41, EpoNi/22.1), in line with a previous study reporting superior transduction efficiency by LLOV-GP (relative to EBOV-, RESTV-and MARV-GP) when bat cell lines were examined [50] . In addition, we were able to confirm previous data that indicated reduced transduction of NHP cells by EBOV2014-GP compared to EBOV1976-GP [47] . This observation is in line with the finding that cynomolgus macaques experimentally infected with the Makona strain of EBOV (i.e. EBOV2014) showed delayed disease progression compared to animals inoculated with EBOV1976 [74] . Collectively, these findings highlight that filovirus GPs can differ markedly in their capacity to mediate entry into cell lines of various species. This finding reflects the diverse nature of the different filovirus species that, despite their taxonomical relatedness, may engage certain host cell-encoded entry factors with different efficiencies.

    Search related documents:
    Co phrase search for related documents
    • bat cell line and filovirus gps: 1
    • bat cell line and fruit bat cell line: 1, 2, 3
    • cell line and different efficiency: 1, 2
    • cell line and disease progression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16
    • cell line and entry factor: 1, 2, 3, 4, 5, 6
    • cell line and filovirus gps: 1, 2, 3, 4
    • cell line and fruit bat cell line: 1, 2, 3
    • cell line and highly efficient entry: 1
    • cynomolgus macaque and disease progression: 1, 2
    • delay disease progression and disease progression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • different efficiency and disease progression: 1
    • disease progression and diverse nature: 1
    • disease progression and entry factor: 1, 2
    • filovirus gps and fruit bat cell line: 1