Author: Hoffmann, Markus; González Hernández, Mariana; Berger, Elisabeth; Marzi, Andrea; Pöhlmann, Stefan
Title: The Glycoproteins of All Filovirus Species Use the Same Host Factors for Entry into Bat and Human Cells but Entry Efficiency Is Species Dependent Document date: 2016_2_22
ID: 146cwh6y_6
Snippet: We comparatively analyzed filovirus GP-driven entry into human, NHP and bat cell lines. The latter were generated from bat species that are believed to constitute the natural reservoir of filoviruses. Our results show that filoviruses use the same entry mechanism for infection of human, NHP and bat cells. However, the efficiency with which the glycoproteins of certain filovirus species interact with host cell factors during the entry process migh.....
Document: We comparatively analyzed filovirus GP-driven entry into human, NHP and bat cell lines. The latter were generated from bat species that are believed to constitute the natural reservoir of filoviruses. Our results show that filoviruses use the same entry mechanism for infection of human, NHP and bat cells. However, the efficiency with which the glycoproteins of certain filovirus species interact with host cell factors during the entry process might differ.
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