Author: Neufeldt, Christopher J.; Joyce, Michael A.; Van Buuren, Nicholas; Levin, Aviad; Kirkegaard, Karla; Gale Jr., Michael; Tyrrell, D. Lorne J.; Wozniak, Richard W.
Title: The Hepatitis C Virus-Induced Membranous Web and Associated Nuclear Transport Machinery Limit Access of Pattern Recognition Receptors to Viral Replication Sites Document date: 2016_2_10
ID: 1kuggdzj_22
Snippet: To determine whether the signal observed for ribosomal proteins correlated with that of RIG-I, cells were transfected with constructs encoding RIG-I-K270A followed by staining with antibodies directed against the FLAG epitope, S6 ribosomal protein, and HCV core. In both uninfected and HCV-infected cells, there was significant overlap observed between RIG-I-K270A and the S6 protein (S3 Fig) . This spatial separation between the MW and the bulk of .....
Document: To determine whether the signal observed for ribosomal proteins correlated with that of RIG-I, cells were transfected with constructs encoding RIG-I-K270A followed by staining with antibodies directed against the FLAG epitope, S6 ribosomal protein, and HCV core. In both uninfected and HCV-infected cells, there was significant overlap observed between RIG-I-K270A and the S6 protein (S3 Fig) . This spatial separation between the MW and the bulk of the ribosomal proteins is consistent with a model in which translation of the viral polyprotein occurs outside of the MW.
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