Author: Wilson, Van G.
Title: Sumoylation at the Host-Pathogen Interface Document date: 2012_4_5
ID: 1awau7hm_35
Snippet: p53 is another cellular tumor suppressor that can elicit both cell cycle arrest and apoptosis in response to infection, so it is a primary target for many viral proteins that seek to limit p53's functions [2] . As discussed in section 4.1, the adenovirus E1B-55K protein is a SUMO ligase that specifically targets p53 and enhances its sumoylation with SUMO1 [74] . This viral enhanced sumoylation contributes to p53 localization and tethering in PML .....
Document: p53 is another cellular tumor suppressor that can elicit both cell cycle arrest and apoptosis in response to infection, so it is a primary target for many viral proteins that seek to limit p53's functions [2] . As discussed in section 4.1, the adenovirus E1B-55K protein is a SUMO ligase that specifically targets p53 and enhances its sumoylation with SUMO1 [74] . This viral enhanced sumoylation contributes to p53 localization and tethering in PML NBs which results in p53 export and accumulation in cytoplasmic aggregates where it is nonfunctional. This clearly constitutes viral hijacking of the sumoylation system to suppress the activity of a host defense protein.
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