Selected article for: "host cell and pathogen pathogen"

Author: Martinez-Martin, Nadia
Title: Technologies for Proteome-Wide Discovery of Extracellular Host-Pathogen Interactions
  • Document date: 2017_2_22
  • ID: 1giy1fow_40
    Snippet: Another prominent example published recently is the identification of host factors that confer susceptibility to the evolutionary related type III secretion systems, T3SS1 and T3SS2, encoded by Vibrio parahaemolyticus [128] . The T3SSs are highly complex nanomachines utilized by gramnegative pathogens to inject a variable repertoire of virulence factors into the cytosol of the eukaryotic cells, enabling pathogen adhesion and internalization of mo.....
    Document: Another prominent example published recently is the identification of host factors that confer susceptibility to the evolutionary related type III secretion systems, T3SS1 and T3SS2, encoded by Vibrio parahaemolyticus [128] . The T3SSs are highly complex nanomachines utilized by gramnegative pathogens to inject a variable repertoire of virulence factors into the cytosol of the eukaryotic cells, enabling pathogen adhesion and internalization of modulation of host processes. Interestingly, using genome-wide CRISPR/Cas9 screens, sulfation and fucosylation of cell surface components were identified as host determinants of T3SS1-and T3SS2mediated cytotoxicity, respectively. The authors hypothesized that interactions between sulfated cell surface molecules such as host proteoglycans and bacterial adhesins act as facilitators of T3SS1 activity, whereas fucosylated glycans on the surface may serve as receptors for T3SS2 components necessary for insertion of the complex in the host membrane [128] . The CRISPR/Cas9 approach has just started to reveal its power as a tool for unbiased identification of novel ePPIs, elegantly exemplified by the identification of CD300lf as the cell surface receptor for noroviruses, which, strikingly, was identified as the main determinant for the tropism of the murine norovirus [42] . Further optimization of this technology will unequivocally signify a tremendous advance for the discovery of extracellular host-pathogen PPIs, the processes underlying host-pathogen interactions and its possible therapeutic applications.

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