Author: Martinez-Martin, Nadia
Title: Technologies for Proteome-Wide Discovery of Extracellular Host-Pathogen Interactions Document date: 2017_2_22
ID: 1giy1fow_45
Snippet: More recently, Pillay and colleagues applied the haploid cell screening approach to the identification of host factors essential for the adeno-associated virus (AAV) serotype 2 infection, one of the leading vectors for virus-based genes therapies [49] . Notably, the most significantly enriched gene in these screens was KIAA0319L, a poorly characterized type I immunoglobulin domain-containing transmembrane protein named hereafter as the AAV recept.....
Document: More recently, Pillay and colleagues applied the haploid cell screening approach to the identification of host factors essential for the adeno-associated virus (AAV) serotype 2 infection, one of the leading vectors for virus-based genes therapies [49] . Notably, the most significantly enriched gene in these screens was KIAA0319L, a poorly characterized type I immunoglobulin domain-containing transmembrane protein named hereafter as the AAV receptor. Among the 46 host factors identified as hits, many were implicated in heparin sulfate proteoglycan biosynthesis as well as a number of proteins that participate in intracellular transport processes. AAV is known to attach to the cells using heparin sulfate proteoglycans and hijacks endosomal trafficking to travel to the nucleus upon invasion of the cell; thus the authors hypothesized that these additional factors may influence virus tropism [49] .
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