Author: Guo, Huichen; Huang, Mei; Yuan, Quan; Wei, Yanquan; Gao, Yuan; Mao, Lejiao; Gu, Lingjun; Tan, Yong Wah; Zhong, Yanxin; Liu, Dingxiang; Sun, Shiqi
Title: The Important Role of Lipid Raft-Mediated Attachment in the Infection of Cultured Cells by Coronavirus Infectious Bronchitis Virus Beaudette Strain Document date: 2017_1_12
ID: 0238bsxb_34
Snippet: Viral infection comprises several steps, and viral attachment to host cells is the first step that determines tissue tropism, host specificity, and viral pathogenicity [34] . Although some viruses can recognize numerous host species, other viruses have limited host ranges because of their requirement for specific host cell receptors. In addition to special receptors, lipid rafts, as membrane components that ubiquitously exist in all cell types [3.....
Document: Viral infection comprises several steps, and viral attachment to host cells is the first step that determines tissue tropism, host specificity, and viral pathogenicity [34] . Although some viruses can recognize numerous host species, other viruses have limited host ranges because of their requirement for specific host cell receptors. In addition to special receptors, lipid rafts, as membrane components that ubiquitously exist in all cell types [35] , are also involved in the regulation of endocytosis, intracellular trafficking of growth factor receptors, and localization of endosomes in cells [36] . A growing number of studies in the past two decades have reported that lipid rafts are crucial in the pathogenesis of many viruses [37, 38] and bacteria [39] . Moreover, lipid rafts are involved in different stages of the viral life cycle, such as viral entry and release.
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