Author: Wilson, Van G.
Title: Sumoylation at the Host-Pathogen Interface Document date: 2012_4_5
ID: 1awau7hm_12
Snippet: In summary, there is growing evidence that many host proteins involved in innate and intrinsic immunity are regulated by sumoylation, thus their function could be dysregulated by viral attacks on the sumoylation system. Alternatively, the SUMO moieties on these host proteins can serve as targeting signals to recruit viral proteins containing one or more SIM sequences. These SUMO-SIM interactions are critical for directing some viral proteins to c.....
Document: In summary, there is growing evidence that many host proteins involved in innate and intrinsic immunity are regulated by sumoylation, thus their function could be dysregulated by viral attacks on the sumoylation system. Alternatively, the SUMO moieties on these host proteins can serve as targeting signals to recruit viral proteins containing one or more SIM sequences. These SUMO-SIM interactions are critical for directing some viral proteins to cellular defense complexes, such as PML NBs, where the viral proteins can subsequently counteract the defense mechanism. Consequently, sumoylation appears to be a highly important component of viral strategies for overcoming host defenses early in infection.
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