Author: Tchitchek, Nicolas; Eisfeld, Amie J; Tisoncik-Go, Jennifer; Josset, Laurence; Gralinski, Lisa E; Bécavin, Christophe; Tilton, Susan C; Webb-Robertson, Bobbie-Jo; Ferris, Martin T; Totura, Allison L; Li, Chengjun; Neumann, Gabriele; Metz, Thomas O; Smith, Richard D; Waters, Katrina M; Baric, Ralph; Kawaoka, Yoshihiro; Katze, Michael G
Title: Specific mutations in H5N1 mainly impact the magnitude and velocity of the host response in mice Document date: 2013_7_29
ID: 1qc72ovc_12
Snippet: In brief, influenza viruses used in this study exhibited a range of lethality, morbidity, and replication in mice. Consistent with our expectations, the VN1203-WT virus was the most virulent, with a very low MLD, the most rapid weight loss, and the highest virus replication at early dpi (day 1 and 2)......
Document: In brief, influenza viruses used in this study exhibited a range of lethality, morbidity, and replication in mice. Consistent with our expectations, the VN1203-WT virus was the most virulent, with a very low MLD, the most rapid weight loss, and the highest virus replication at early dpi (day 1 and 2).
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