Author: Tchitchek, Nicolas; Eisfeld, Amie J; Tisoncik-Go, Jennifer; Josset, Laurence; Gralinski, Lisa E; Bécavin, Christophe; Tilton, Susan C; Webb-Robertson, Bobbie-Jo; Ferris, Martin T; Totura, Allison L; Li, Chengjun; Neumann, Gabriele; Metz, Thomas O; Smith, Richard D; Waters, Katrina M; Baric, Ralph; Kawaoka, Yoshihiro; Katze, Michael G
Title: Specific mutations in H5N1 mainly impact the magnitude and velocity of the host response in mice Document date: 2013_7_29
ID: 1qc72ovc_28
Snippet: Strikingly, whereas VN1203-PB1F2del VC and MC profiles at 10 3 PFU were intermediate between VN1203-WT 10 2 and 10 3 , at the highest dose (10 4 PFU), both the peak of VC at 2 dpi and the peak of MC at 7 dpi were higher than VN1203-WT at the same dose (Figures 4 and 5C ). It should be noted that both body weight loss and virus replication were similar at this dose between the VN1203-WT and this mutant (Figure 1) . Moreover, during the course of .....
Document: Strikingly, whereas VN1203-PB1F2del VC and MC profiles at 10 3 PFU were intermediate between VN1203-WT 10 2 and 10 3 , at the highest dose (10 4 PFU), both the peak of VC at 2 dpi and the peak of MC at 7 dpi were higher than VN1203-WT at the same dose (Figures 4 and 5C ). It should be noted that both body weight loss and virus replication were similar at this dose between the VN1203-WT and this mutant (Figure 1) . Moreover, during the course of infection, four out of the five mice died between 4 and 7 dpi, indicating a high virulence of this mutant at 10 4 PFU.
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