Author: Kouokam, Joseph Calvin; Lasnik, Amanda B.; Palmer, Kenneth E.
Title: Studies in a Murine Model Confirm the Safety of Griffithsin and Advocate Its Further Development as a Microbicide Targeting HIV-1 and Other Enveloped Viruses Document date: 2016_11_17
ID: 096348l5_37
Snippet: in Figure 6A , the animals displayed similar body weights throughout the experiment, whether treated with GRFT or PBS, regardless of the administration route. The same observation was made for the relative spleen weights ( Figure 6B ). In accordance to these results, no activation of spleen Bor T-cells was found after GRFT administration regardless of the route, as evaluated using B220 and CD69 markers, respectively ( Figure 6C,D) . These results.....
Document: in Figure 6A , the animals displayed similar body weights throughout the experiment, whether treated with GRFT or PBS, regardless of the administration route. The same observation was made for the relative spleen weights ( Figure 6B ). In accordance to these results, no activation of spleen Bor T-cells was found after GRFT administration regardless of the route, as evaluated using B220 and CD69 markers, respectively ( Figure 6C,D) . These results further demonstrated that GRFT has an excellent safety profile as a microbicide.
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