Author: Wilson, Van G.
Title: Sumoylation at the Host-Pathogen Interface Document date: 2012_4_5
ID: 1awau7hm_24
Snippet: There are two known examples of viral proteins targeting SUMO ligases, the human papillomavirus (HPV) E6 protein [86] and the Ebola virus VP35 protein [87] . The HPV E6 binds the PIASy SUMO ligase to inhibit sumoylation of PIASy substrates [86] . E6 did not induce degradation of PIASy so the inhibition of activity appears to be a direct result of binding. This binding and inhibitory activity was restricted to the high risk HPV 16 E6 protein and w.....
Document: There are two known examples of viral proteins targeting SUMO ligases, the human papillomavirus (HPV) E6 protein [86] and the Ebola virus VP35 protein [87] . The HPV E6 binds the PIASy SUMO ligase to inhibit sumoylation of PIASy substrates [86] . E6 did not induce degradation of PIASy so the inhibition of activity appears to be a direct result of binding. This binding and inhibitory activity was restricted to the high risk HPV 16 E6 protein and was absent in the low risk HPV11 E6 protein.
Search related documents:
Co phrase search for related documents- activity inhibition and high risk: 1, 2
- activity inhibition and low risk: 1
- activity inhibition and viral protein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- binding direct result and direct result: 1, 2
- direct result and Ebola virus: 1, 2, 3
- direct result and high risk: 1, 2, 3, 4, 5, 6, 7, 8
- direct result and low risk: 1, 2
- direct result and viral protein: 1, 2
- Ebola virus and high risk: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- Ebola virus and HPV human papillomavirus: 1, 2, 3, 4
- Ebola virus and human papillomavirus: 1, 2, 3, 4, 5
- Ebola virus and low risk: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
- Ebola virus and viral protein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- high risk and HPV human papillomavirus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- high risk and human papillomavirus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- high risk and know example: 1, 2
- high risk and low risk: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- HPV human papillomavirus and human papillomavirus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- HPV human papillomavirus and low risk: 1, 2, 3
Co phrase search for related documents, hyperlinks ordered by date