Author: El-Faham, Ayman; Farooq, Muhammad; Khattab, Sherine N.; Abutaha, Nael; Wadaan, Mohammad A.; Ghabbour, Hazem A.; Fun, Hoong-Kun
Title: Synthesis, Characterization, and Anti-Cancer Activity of Some New N'-(2-Oxoindolin-3-ylidene)-2-propylpentane hydrazide-hydrazones Derivatives Document date: 2015_8_13
ID: 0dddrh4e_1
Snippet: Hydrazide-hydrazone derivatives are molecules containing a highly reactive group (CO-NH-N=CH) and considered to be a good candidate for development of a new drug [1] . Recently, hydrazide-hydrazones have been considered to be of great interest in medicinal chemistry due to their diverse biological properties, including anti-microbial [2] [3] [4] , anti-mycobacterial [5, 6] , anti-convulsant [7] , analgesic [8] , anti-inflammatory [9] , anti-plate.....
Document: Hydrazide-hydrazone derivatives are molecules containing a highly reactive group (CO-NH-N=CH) and considered to be a good candidate for development of a new drug [1] . Recently, hydrazide-hydrazones have been considered to be of great interest in medicinal chemistry due to their diverse biological properties, including anti-microbial [2] [3] [4] , anti-mycobacterial [5, 6] , anti-convulsant [7] , analgesic [8] , anti-inflammatory [9] , anti-platelet [10] , anti-tubercular [10] [11] [12] [13] , and anti-tumoral activities [14] [15] [16] [17] [18] [19] . In addition, hydrazide-hydrazones have been reported to elicit anti-cancer [18] [19] [20] [21] and anti-HIV properties [22] and they are therefore increasingly considered to be of great value in medicinal chemistry [16, [23] [24] [25] [26] [27] .
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