Author: Martinez-Martin, Nadia
Title: Technologies for Proteome-Wide Discovery of Extracellular Host-Pathogen Interactions Document date: 2017_2_22
ID: 1giy1fow_27
Snippet: The protein microarrays have represented one of the most fruitful approaches for unbiased determination of ePPIs, including host-pathogen interactions. Nevertheless, one of the main limitations of this technology is the need to generate comprehensive libraries, a process that is resource consuming and often not available to many researchers [53, 93] . Consequently, although some of the available arrays were designed to cover a significant fractio.....
Document: The protein microarrays have represented one of the most fruitful approaches for unbiased determination of ePPIs, including host-pathogen interactions. Nevertheless, one of the main limitations of this technology is the need to generate comprehensive libraries, a process that is resource consuming and often not available to many researchers [53, 93] . Consequently, although some of the available arrays were designed to cover a significant fraction of the human proteome, any discoveries made using these platforms are limited to the proteins present in each array. The current libraries are likely to continue expanding alongside innovative approaches to facilitate sensitive detection of ePPI using protein microarray formats.
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