Author: El-Faham, Ayman; Farooq, Muhammad; Khattab, Sherine N.; Abutaha, Nael; Wadaan, Mohammad A.; Ghabbour, Hazem A.; Fun, Hoong-Kun
Title: Synthesis, Characterization, and Anti-Cancer Activity of Some New N'-(2-Oxoindolin-3-ylidene)-2-propylpentane hydrazide-hydrazones Derivatives Document date: 2015_8_13
ID: 0dddrh4e_23
Snippet: A solution of valproic hydrazide 2 (316 mg, 2 mmol) in ethanol (20 mL) was added to a solution of substituted isatin 3a-h (1 mmol) in ethanol (20 mL), and glacial acetic acid (2 drops); the reaction mixture was refluxed for 3-4 h. The product was separated out on cooling, filtered, and recrystallized from ethanol or ethylacetate to afford N′-(2-oxoindolin-3-ylidene)-2-propylpentanehydrazide derivatives 4a-h......
Document: A solution of valproic hydrazide 2 (316 mg, 2 mmol) in ethanol (20 mL) was added to a solution of substituted isatin 3a-h (1 mmol) in ethanol (20 mL), and glacial acetic acid (2 drops); the reaction mixture was refluxed for 3-4 h. The product was separated out on cooling, filtered, and recrystallized from ethanol or ethylacetate to afford N′-(2-oxoindolin-3-ylidene)-2-propylpentanehydrazide derivatives 4a-h.
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