Author: Grabiec, Aleksander M.; Hussell, Tracy
Title: The role of airway macrophages in apoptotic cell clearance following acute and chronic lung inflammation Document date: 2016_3_8
ID: 1f47gvys_31
Snippet: While defective efferocytosis by airway macrophages in CF patients is a consequence of the ongoing inflammatory response and/or microbial infection, impaired apoptotic cell uptake by epithelial cells might be directly related to the lack of CFTR expression. CFTR-deficient epithelial cells express significantly increased levels of RhoA, which is a negative regulator of efferoctyosis, and RhoA inhibition restores their phagocytic function [111] . I.....
Document: While defective efferocytosis by airway macrophages in CF patients is a consequence of the ongoing inflammatory response and/or microbial infection, impaired apoptotic cell uptake by epithelial cells might be directly related to the lack of CFTR expression. CFTR-deficient epithelial cells express significantly increased levels of RhoA, which is a negative regulator of efferoctyosis, and RhoA inhibition restores their phagocytic function [111] . It remains to be determined if a similar mechanism regulates bronchial epithelial cell efferocytosis in patients with CF.
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