Author: Tan, Jinzhi; Vonrhein, Clemens; Smart, Oliver S.; Bricogne, Gerard; Bollati, Michela; Kusov, Yuri; Hansen, Guido; Mesters, Jeroen R.; Schmidt, Christian L.; Hilgenfeld, Rolf
Title: The SARS-Unique Domain (SUD) of SARS Coronavirus Contains Two Macrodomains That Bind G-Quadruplexes Document date: 2009_5_15
ID: 1aqt65cc_25
Snippet: Coronavirus replication in the perinuclear region of the cell is localized to double-membrane vesicles that have been hijacked from the endoplasmic reticulum or late endosomes [37] [38] [39] [40] . These vesicles are around 200-350 nm in diameter and present alone or as clusters in the cytosol [38] . The milieu inside or at the surface of these vesicles is unknown, but it is well possible that it is partially oxidative. It has also been speculate.....
Document: Coronavirus replication in the perinuclear region of the cell is localized to double-membrane vesicles that have been hijacked from the endoplasmic reticulum or late endosomes [37] [38] [39] [40] . These vesicles are around 200-350 nm in diameter and present alone or as clusters in the cytosol [38] . The milieu inside or at the surface of these vesicles is unknown, but it is well possible that it is partially oxidative. It has also been speculated [25] that formation of disulfide bonds may be a way for the coronaviral Nsps to function in the presence of the oxidative stress that is the consequence of the viral infection [41] [42] [43] .
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