Author: Lu, Yujie; Liu, Wenjuan; Zhang, Man; Deng, Yanfang; Jiang, Min; Bai, Gang
Title: The Screening Research of NF-?B Inhibitors from Moutan Cortex Based on Bioactivity-Integrated UPLC-Q/TOF-MS Document date: 2019_3_3
ID: 1ahxau9k_20
Snippet: Compounds. Oxypaeoniflorin, galloylpaeoniflorin, benzoyloxypaeoniflorin, and mudanpioside C have the same structural characteristics, all of which have paeoniflorin as the mother nucleus structure. Since the generation of drug efficacy mainly depends on their chemical structure, we selected paeoniflorin, the mother nucleus of the four compounds, as a representative component to study their anti-inflammatory activity. For verification of NF-B inhi.....
Document: Compounds. Oxypaeoniflorin, galloylpaeoniflorin, benzoyloxypaeoniflorin, and mudanpioside C have the same structural characteristics, all of which have paeoniflorin as the mother nucleus structure. Since the generation of drug efficacy mainly depends on their chemical structure, we selected paeoniflorin, the mother nucleus of the four compounds, as a representative component to study their anti-inflammatory activity. For verification of NF-B inhibitory activity, varying concentrations (10 −4 mol/L, 10 −5 mol/L, and 10 −6 mol/L) of three ingredients (gallic acid, paeoniflorin, and paeonol) were chosen for dual-luciferase reporter assay. As shown in Figure 3 , gallic acid, paeoniflorin, and paeonol all showed significant NF-B inhibitory effects.
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