Selected article for: "additional file and clustering method"
Author: Tchitchek, Nicolas; Eisfeld, Amie J; Tisoncik-Go, Jennifer; Josset, Laurence; Gralinski, Lisa E; Bécavin, Christophe; Tilton, Susan C; Webb-Robertson, Bobbie-Jo; Ferris, Martin T; Totura, Allison L; Li, Chengjun; Neumann, Gabriele; Metz, Thomas O; Smith, Richard D; Waters, Katrina M; Baric, Ralph; Kawaoka, Yoshihiro; Katze, Michael G
Title: Specific mutations in H5N1 mainly impact the magnitude and velocity of the host response in mice
  • Document date: 2013_7_29
    • ID: 1qc72ovc_99
    Snippet: Additional file 6: Figure S3 . Heatmap and over-represented pathways of the host response to VN1203-WT and VN1203-NS1trunc at 1 dpi. (A) Heatmap of the transcript expression signals for the VN1203-WT and VN1203-NS1trunc infected transcriptomic profiles at 1 day-post-infection and for the 10 4 PFU inoculation dosage. Values are shown as log2 ratioed to the mocks infected samples. The dendrogramm representing transcripts clustering has been constru.....
    Document: Additional file 6: Figure S3 . Heatmap and over-represented pathways of the host response to VN1203-WT and VN1203-NS1trunc at 1 dpi. (A) Heatmap of the transcript expression signals for the VN1203-WT and VN1203-NS1trunc infected transcriptomic profiles at 1 day-post-infection and for the 10 4 PFU inoculation dosage. Values are shown as log2 ratioed to the mocks infected samples. The dendrogramm representing transcripts clustering has been constructed using the Euclidian metric and complete-link clustering method. (B) Functional enrichment on the 800 transcripts found as over-regulated in VN1203-NS1trunc. 104 significantly over-represented pathways have been identified (p-value cutoff of 0.05) and the top 45 is indicated. For each top over-represented canonical pathway the p-value (shown as -log10) is indicated.

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