Author: Shapira, Assaf; Benhar, Itai
Title: Toxin-Based Therapeutic Approaches Document date: 2010_10_28
ID: 00cf294x_30
Snippet: Prostate cancer (PCA) is the most common cancer diagnosed in men and a leading cause of cancer deaths [367] . Normal and malignant prostate epithelia specifically express the kallikrein protease prostate-specific antigen (PSA), a serine protease with trypsin-and chymotrypsin-like activities that is responsible for liquifaction of semen [368, 369] . PSA gene regulatory regions are prime candidates to direct prostate-specific expression [370] [371].....
Document: Prostate cancer (PCA) is the most common cancer diagnosed in men and a leading cause of cancer deaths [367] . Normal and malignant prostate epithelia specifically express the kallikrein protease prostate-specific antigen (PSA), a serine protease with trypsin-and chymotrypsin-like activities that is responsible for liquifaction of semen [368, 369] . PSA gene regulatory regions are prime candidates to direct prostate-specific expression [370] [371] [372] [373] . When placed under the transcriptional regulation of the PSA promoter, the diphtheria toxin A chain (DT-A) encoding gene which was delivered by an adenoviral vector showed strong inhibition of tumor growth in a PSA-producing prostate tumor xenograft mouse model while not affecting non-PSA producing tumor xenografts [339] . A PSA promoter-based lentiviral vector has also been used as a mean for DT-A gene delivery, leading to specific eradication of prostate tumor xenografts in nude mice following a single intratumoral injection. Repetitive injections were shown to inhibit the growth of recurrent tumors [374] .
Search related documents:
Co phrase search for related documents- recurrent tumor and tumor growth: 1, 2
- recurrent tumor and xenograft mouse: 1
- recurrent tumor and xenograft mouse model: 1
- recurrent tumor growth and tumor growth: 1
- regulatory region and transcriptional regulation: 1
- serine protease and strong inhibition: 1, 2, 3, 4
- serine protease and transcriptional regulation: 1, 2
- serine protease and tumor growth: 1
- single intratumoral injection and tumor growth: 1
- specific eradication and transcriptional regulation: 1
- strong inhibition and tumor growth: 1, 2, 3
- strong inhibition and tumor growth strong inhibition: 1, 2
- transcriptional regulation and tumor growth: 1, 2
- tumor growth and xenograft mouse: 1, 2, 3, 4, 5, 6, 7
- tumor growth and xenograft mouse model: 1, 2, 3, 4
- tumor xenograft and xenograft mouse: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- tumor xenograft and xenograft mouse model: 1, 2, 3, 4, 5, 6
- tumor xenograft mouse model and xenograft mouse: 1, 2, 3, 4, 5, 6, 7
- tumor xenograft mouse model and xenograft mouse model: 1, 2, 3, 4, 5, 6, 7
Co phrase search for related documents, hyperlinks ordered by date