Author: Mathew, Suneeth F.; Crowe-McAuliffe, Caillan; Graves, Ryan; Cardno, Tony S.; McKinney, Cushla; Poole, Elizabeth S.; Tate, Warren P.
Title: The Highly Conserved Codon following the Slippery Sequence Supports -1 Frameshift Efficiency at the HIV-1 Frameshift Site Document date: 2015_3_25
ID: 10p3mth2_40
Snippet: The Codon following the Slippery Sequence Supports HIV Frameshifting observed this as well, but also observed this in cells transfected with a control shRNA sequence, indicating a non-specific effect in our system. While it is difficult to reconcile fully the two data sets, we note that the former study had a greater eRF1 knockdown (*80%) compared with our more modest 50%. The HIV-1 frameshift element and reporter translations may have some unexp.....
Document: The Codon following the Slippery Sequence Supports HIV Frameshifting observed this as well, but also observed this in cells transfected with a control shRNA sequence, indicating a non-specific effect in our system. While it is difficult to reconcile fully the two data sets, we note that the former study had a greater eRF1 knockdown (*80%) compared with our more modest 50%. The HIV-1 frameshift element and reporter translations may have some unexplained interaction with the shRNAs not seen with the readthrough or +1 antizyme translations (discussed above).
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