Author: ten Oever, Jaap; Kox, Matthijs; van de Veerdonk, Frank L; Mothapo, Khutso M; Slavcovici, Adriana; Jansen, Tim L; Tweehuysen, Lieke; Giamarellos-Bourboulis, Evangelos J; Schneeberger, Peter M; Wever, Peter C; Stoffels, Monique; Simon, Anna; van der Meer, Jos WM; Johnson, Melissa D; Kullberg, Bart-Jan; Pickkers, Peter; Pachot, Alexandre; Joosten, Leo AB; Netea, Mihai G
Title: The discriminative capacity of soluble Toll-like receptor (sTLR)2 and sTLR4 in inflammatory diseases Document date: 2014_11_19
ID: 0zkeoa1z_33
Snippet: The present study is an important initial proof-ofprinciple report on the role of sTLR2 and sTLR4 during a broad panel of human infections and autoinflammatory diseases. Shedding of sTLR2 and sTLR4 is not confined to stimulation of its corresponding cell surface receptor, but it is a broader effect upon stimulation of innate immune cells through pattern recognition receptors. We report the significant increase of sTLR2 and sTLR4 both in experimen.....
Document: The present study is an important initial proof-ofprinciple report on the role of sTLR2 and sTLR4 during a broad panel of human infections and autoinflammatory diseases. Shedding of sTLR2 and sTLR4 is not confined to stimulation of its corresponding cell surface receptor, but it is a broader effect upon stimulation of innate immune cells through pattern recognition receptors. We report the significant increase of sTLR2 and sTLR4 both in experimental models of human endotoxemia, as well as in the circulation of patients with infections. This suggests an important role of soluble TLRs in the modulation of inflammation during infections and the potential to use these tests as diagnostic markers. Therefore, larger validation studies in larger patient cohorts are warranted in order to be able to draw definitive conclusions regarding the diagnostic usefulness of sTLR2 and sTLR4 in human inflammatory diseases.
Search related documents:
Co phrase search for related documents- cell surface and corresponding cell surface receptor stimulation: 1
- cell surface and experimental model: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
- cell surface and human endotoxemia: 1
- cell surface and human infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73
- cell surface and human inflammatory disease: 1
- cell surface and immune cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76
- cell surface and important role: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73
- cell surface and infection patient: 1, 2, 3, 4, 5
- cell surface and inflammation modulation: 1
- cell surface and inflammatory disease: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20
- cell surface and innate immune cell: 1, 2, 3, 4, 5, 6, 7, 8
- cell surface and innate immune cell stimulation: 1
- cell surface and pattern recognition: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
- cell surface and pattern recognition receptor: 1
- cell surface and present study: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71
- cell surface and significant increase: 1, 2, 3, 4, 5
- cell surface and validation study: 1, 2
- cell surface receptor and corresponding cell surface receptor: 1, 2
- cell surface receptor and corresponding cell surface receptor stimulation: 1
Co phrase search for related documents, hyperlinks ordered by date