Author: Yang, Darong; Li, Nan L.; Wei, Dahai; Liu, Baoming; Guo, Fang; Elbahesh, Husni; Zhang, Yunzhi; Zhou, Zhi; Chen, Guo-Yun; Li, Kui
Title: The E3 ligase TRIM56 is a host restriction factor of Zika virus and depends on its RNA-binding activity but not miRNA regulation, for antiviral function Document date: 2019_6_28
ID: 1nr0hggt_4
Snippet: We have previously demonstrated that TRIM56, a RING-type E3 ligase of the tripartite motif protein family, puts a check on intracellular RNA replication of DENV serotype 2 (DENV2), YFV, and bovine viral diarrhea virus (BVDV) in cell culture [24, 25] . Although the inhibitory effects on these viruses invariably rely upon the E3 ligase activity as well as the Cterminal integrity of TRIM56 [24, 25] , the underlying mechanism remains elusive. In addi.....
Document: We have previously demonstrated that TRIM56, a RING-type E3 ligase of the tripartite motif protein family, puts a check on intracellular RNA replication of DENV serotype 2 (DENV2), YFV, and bovine viral diarrhea virus (BVDV) in cell culture [24, 25] . Although the inhibitory effects on these viruses invariably rely upon the E3 ligase activity as well as the Cterminal integrity of TRIM56 [24, 25] , the underlying mechanism remains elusive. In addition, whether the antiviral spectrum of TRIM56 can be extended to other viruses within the flavivirus genus, especially ZIKV, is an intriguing and important question to answer.
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