Author: Yang, Darong; Li, Nan L.; Wei, Dahai; Liu, Baoming; Guo, Fang; Elbahesh, Husni; Zhang, Yunzhi; Zhou, Zhi; Chen, Guo-Yun; Li, Kui
Title: The E3 ligase TRIM56 is a host restriction factor of Zika virus and depends on its RNA-binding activity but not miRNA regulation, for antiviral function Document date: 2019_6_28
ID: 1nr0hggt_33
Snippet: Since the recent ZIKV outbreaks were caused by viruses of Asian lineage, we sought to verify the anti-ZIKV effect of TRIM56 using the PRVABC59 strain, an Asian lineage ZIKV [49] . When challenged with this virus, control cells without FH-TRIM56 expression supported abundant expression of ZIKV E protein at 72 h.p.i. (Fig 2A, lanes 3 and 5) , whereas cells constitutively expressing FH-TRIM56 had diminished viral protein levels (lanes 4 and 6), even.....
Document: Since the recent ZIKV outbreaks were caused by viruses of Asian lineage, we sought to verify the anti-ZIKV effect of TRIM56 using the PRVABC59 strain, an Asian lineage ZIKV [49] . When challenged with this virus, control cells without FH-TRIM56 expression supported abundant expression of ZIKV E protein at 72 h.p.i. (Fig 2A, lanes 3 and 5) , whereas cells constitutively expressing FH-TRIM56 had diminished viral protein levels (lanes 4 and 6), even when infected at a high MOI (MOI = 2, compare lanes 6 vs 5). Data on progeny virus production in culture supernatants (Fig 2B) also confirmed the inhibitory effect of TRIM56 on ZIKV-PRVABC59 propagation.
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