Selected article for: "human peripheral blood and peripheral blood"

Author: Zapata, Juan Carlos; Carrion, Ricardo; Patterson, Jean L.; Crasta, Oswald; Zhang, Yan; Mani, Sachin; Jett, Marti; Poonia, Bhawna; Djavani, Mahmoud; White, David M.; Lukashevich, Igor S.; Salvato, Maria S.
Title: Transcriptome Analysis of Human Peripheral Blood Mononuclear Cells Exposed to Lassa Virus and to the Attenuated Mopeia/Lassa Reassortant 29 (ML29), a Vaccine Candidate
  • Document date: 2013_9_12
  • ID: 0epeljaf_16
    Snippet: The virulent Lassa fever virus (LASV) and the nonpathogenic Mopeia virus (MOPV) infect rodents and, incidentally, people in West Africa. The mechanism of LASV damage in human beings is unclear. There is no licensed Lassa fever vaccine and therapeutic intervention is usually too late. The ML29 vaccine candidate derived from Lassa and Mopeia viruses protects rodents and primates from Lassa fever disease. Peripheral blood mononuclear cells from heal.....
    Document: The virulent Lassa fever virus (LASV) and the nonpathogenic Mopeia virus (MOPV) infect rodents and, incidentally, people in West Africa. The mechanism of LASV damage in human beings is unclear. There is no licensed Lassa fever vaccine and therapeutic intervention is usually too late. The ML29 vaccine candidate derived from Lassa and Mopeia viruses protects rodents and primates from Lassa fever disease. Peripheral blood mononuclear cells from healthy human subjects were exposed to either LASV or ML29 in order to identify early cellular responses that could be attributed to the difference in virulence between the two viruses. Differential expression of interferon-stimulated genes as well as coagulation-related genes could lead to an explanation for Lassa fever pathogenesis and indicate protective treatments for Lassa fever disease.

    Search related documents:
    Co phrase search for related documents
    • blood mononuclear and differential expression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
    • blood mononuclear and fever disease: 1, 2
    • blood mononuclear and fever vaccine: 1
    • blood mononuclear and fever virus: 1, 2, 3, 4, 5, 6, 7, 8
    • blood mononuclear and Lassa fever disease: 1
    • blood mononuclear cell and cellular response: 1, 2, 3, 4, 5
    • blood mononuclear cell and fever vaccine: 1
    • cellular response and differential expression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
    • cellular response and fever vaccine: 1
    • cellular response and fever virus: 1, 2, 3, 4, 5, 6
    • differential expression and fever disease: 1, 2
    • differential expression and fever virus: 1
    • differential expression and interferon stimulate: 1
    • differential expression and Lassa fever disease: 1
    • fever disease and Lassa fever disease: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • fever pathogenesis and Lassa fever disease: 1
    • fever virus and interferon stimulate: 1
    • fever virus and Lassa fever disease: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20
    • healthy human subject and human subject: 1, 2, 3, 4, 5, 6