Author: Zapata, Juan Carlos; Carrion, Ricardo; Patterson, Jean L.; Crasta, Oswald; Zhang, Yan; Mani, Sachin; Jett, Marti; Poonia, Bhawna; Djavani, Mahmoud; White, David M.; Lukashevich, Igor S.; Salvato, Maria S.
Title: Transcriptome Analysis of Human Peripheral Blood Mononuclear Cells Exposed to Lassa Virus and to the Attenuated Mopeia/Lassa Reassortant 29 (ML29), a Vaccine Candidate Document date: 2013_9_12
ID: 0epeljaf_3
Snippet: The disease mechanism for LF is still not clearly understood. As with other VHF, events that determine LF fatal outcome occur very early in the disease and depend on the host immune system [12] , [13] . Macrophages (MP) and dendritic cells (DC) are the initial targets of infection, followed by viremic seeding of a wide variety of cells and organs. High viremia and elevated levels of AST in plasma are two major risk factors predicting fatal outcom.....
Document: The disease mechanism for LF is still not clearly understood. As with other VHF, events that determine LF fatal outcome occur very early in the disease and depend on the host immune system [12] , [13] . Macrophages (MP) and dendritic cells (DC) are the initial targets of infection, followed by viremic seeding of a wide variety of cells and organs. High viremia and elevated levels of AST in plasma are two major risk factors predicting fatal outcome [14] . Although the most consistent pathologic finding is hepatocellular necrosis, the extent of liver damage is usually insufficient to implicate hepatic failure as the cause of death [14] , [2] . Functional damage of platelets and endothelial cells seems to play an important role [15] , [16] , [2] . However, contribution of proand anti-inflammatory stimuli to LF pathogenesis is not clearly understood.
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