Author: Meier, Anita F.; Suter, Mark; Schraner, Elisabeth M.; Humbel, Bruno M.; Tobler, Kurt; Ackermann, Mathias; Laimbacher, Andrea S.
Title: Transfer of Anti-Rotavirus Antibodies during Pregnancy and in Milk Following Maternal Vaccination with a Herpes Simplex Virus Type-1 Amplicon Vector Document date: 2017_2_16
ID: 09hmet7r_27
Snippet: We further tested if the vaccine-induced immune response in the suckling mice was sufficient to protect them from the symptoms of RV infection. Therefore, we challenged the pups of all groups (either swapped or non-swapped) with oral gavage of mouse RV-strain EDIM, 10× diarrhea dose 50 (DD50)-at two to five days after birth. All pups developed diarrhea within comparable periods of incubation time. Thus, the immune response raised was not suffici.....
Document: We further tested if the vaccine-induced immune response in the suckling mice was sufficient to protect them from the symptoms of RV infection. Therefore, we challenged the pups of all groups (either swapped or non-swapped) with oral gavage of mouse RV-strain EDIM, 10× diarrhea dose 50 (DD50)-at two to five days after birth. All pups developed diarrhea within comparable periods of incubation time. Thus, the immune response raised was not sufficient to protect the suckling mice from RV induced symptoms in our experimental settings.
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