Author: Mathew, Suneeth F.; Crowe-McAuliffe, Caillan; Graves, Ryan; Cardno, Tony S.; McKinney, Cushla; Poole, Elizabeth S.; Tate, Warren P.
Title: The Highly Conserved Codon following the Slippery Sequence Supports -1 Frameshift Efficiency at the HIV-1 Frameshift Site Document date: 2015_3_25
ID: 10p3mth2_55
Snippet: HIV-1 is unusual among frameshifting retroviruses in that it lacks a pseudoknot stimulator of PRF. Early work on the Rous sarcoma virus −1 PRF element, which contains a pseudoknot, found that mutations in the intercodon (naturally a stop codon in this instance) did not affect frameshift efficiency. Amino acid sequencing by Edman degradation did not detect the predicted product from 'late' −1 PRF that could be translated if the intercodon were.....
Document: HIV-1 is unusual among frameshifting retroviruses in that it lacks a pseudoknot stimulator of PRF. Early work on the Rous sarcoma virus −1 PRF element, which contains a pseudoknot, found that mutations in the intercodon (naturally a stop codon in this instance) did not affect frameshift efficiency. Amino acid sequencing by Edman degradation did not detect the predicted product from 'late' −1 PRF that could be translated if the intercodon were occupying the A site in the Rous sarcoma virus frameshift element [78] , [79] . We propose that the late −1 PRF event we have observed in the M-type HIV-1 element may not be common to other frameshifting retroviruses that utilise a pseudoknot structural element, a hypothesis that we are currently investigating.
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