Transfer of Anti-Rotavirus Antibodies during Pregnancy and in Milk Following Maternal Vaccination with a Herpes Simplex Virus Type-1 Amplicon Vector

Meier, Anita F.; Suter, Mark; Schraner, Elisabeth M.; Humbel, Bruno M.; Tobler, Kurt; Ackermann, Mathias; Laimbacher, Andrea S.

In the adult mouse model, fecal IgA antibodies against VP6 have been the main correlate for protection against RV infection and it has been suggested that VP6 specific antibodies are taken up by the polymeric Ig receptor of the infected enterocyte neutralizing RV intracellularly [40] . However, the passive transfer of VP6-specific antibodies to newborns was not sufficient to protect against diarrhea [27, 31, 41] . Coste et al. demonstrated that nasal immunization of mice with purified TLPs assembled in insect cells and comprising VP2, VP6, and VP7 triggered high milk and serum antibody titers. Furthermore, milk but not serum antibodies were associated to the protection of suckling mice and that antibodies to VP7 played a crucial role [27] .