Author: Mathew, Suneeth F.; Crowe-McAuliffe, Caillan; Graves, Ryan; Cardno, Tony S.; McKinney, Cushla; Poole, Elizabeth S.; Tate, Warren P.
Title: The Highly Conserved Codon following the Slippery Sequence Supports -1 Frameshift Efficiency at the HIV-1 Frameshift Site Document date: 2015_3_25
ID: 10p3mth2_45
Snippet: For translation to proceed through the secondary structural stem-loop in HIV-1, the thermodynamically weaker lower stem would unwind to allow the slippery sequence to occupy the P and A sites (UUU UUA) (Fig. 7B) . Slippage from the P and A sites may now occur as previously observed [26] , [67] ; that is, a portion of ribosomes undergo canonical pre-translocational frameshifting. The data presented in this paper indicates, however, that in a subst.....
Document: For translation to proceed through the secondary structural stem-loop in HIV-1, the thermodynamically weaker lower stem would unwind to allow the slippery sequence to occupy the P and A sites (UUU UUA) (Fig. 7B) . Slippage from the P and A sites may now occur as previously observed [26] , [67] ; that is, a portion of ribosomes undergo canonical pre-translocational frameshifting. The data presented in this paper indicates, however, that in a substantial fraction of ribosomal passages the translating ribosome would maintain the existing reading frame and would simply be 'slowed down' by the building tension (Fig. 7C) [64] .
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