Author: Hoffmann, Markus; González Hernández, Mariana; Berger, Elisabeth; Marzi, Andrea; Pöhlmann, Stefan
Title: The Glycoproteins of All Filovirus Species Use the Same Host Factors for Entry into Bat and Human Cells but Entry Efficiency Is Species Dependent Document date: 2016_2_22
ID: 146cwh6y_1
Snippet: Filovirus infection can cause a life threatening hemorrhagic fever (e.g. Ebola virus disease, EVD) in non-human primates (NHP) and humans, with case-fatality rates of up to 90%. Before 2013, filovirus outbreaks in human populations were restricted to remote areas in Central Africa and were associated with less than 500 cases. The Ebola virus (EBOV) outbreak in Guinea in 2013 resulted for the first time in viral spread from rural to densely popula.....
Document: Filovirus infection can cause a life threatening hemorrhagic fever (e.g. Ebola virus disease, EVD) in non-human primates (NHP) and humans, with case-fatality rates of up to 90%. Before 2013, filovirus outbreaks in human populations were restricted to remote areas in Central Africa and were associated with less than 500 cases. The Ebola virus (EBOV) outbreak in Guinea in 2013 resulted for the first time in viral spread from rural to densely populated areas and had severe consequences: The Ebola virus disease (EVD) epidemic affected major cities in Guinea, Liberia and Sierra Leone and caused 11,312 deaths (as of 11 October 2015) . Moreover, secondary infections occurred in countries not hit by the epidemic, including the USA and Spain. Thus, filoviruses constitute a global health threat.
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