Author: Mathew, Suneeth F.; Crowe-McAuliffe, Caillan; Graves, Ryan; Cardno, Tony S.; McKinney, Cushla; Poole, Elizabeth S.; Tate, Warren P.
Title: The Highly Conserved Codon following the Slippery Sequence Supports -1 Frameshift Efficiency at the HIV-1 Frameshift Site Document date: 2015_3_25
ID: 10p3mth2_46
Snippet: As the intercodon occupies the A site, the stable upper stem blocks the mRNA entry tunnel and resistance to the forward movement of the RNA would further slow the progress of the ribosome. In our model, this resistance created within the HIV-1 element would disrupt the canonical elongation events of some of these ribosomes when the intercodon occupies the A site (Fig. 7C) . As already suggested [26] , an incomplete translocation of the tRNAs and .....
Document: As the intercodon occupies the A site, the stable upper stem blocks the mRNA entry tunnel and resistance to the forward movement of the RNA would further slow the progress of the ribosome. In our model, this resistance created within the HIV-1 element would disrupt the canonical elongation events of some of these ribosomes when the intercodon occupies the A site (Fig. 7C) . As already suggested [26] , an incomplete translocation of the tRNAs and mRNA may occur resulting in distortion of the tRNAs in the P and E sites, similar to that seen with the P site tRNA in cryo-EM structures [63] , and there may be a 'disturbed' occupation of the A site by the intercodon (Fig. 7C) [30] .
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