Selected article for: "stop signal and weak stop signal"

Author: Mathew, Suneeth F.; Crowe-McAuliffe, Caillan; Graves, Ryan; Cardno, Tony S.; McKinney, Cushla; Poole, Elizabeth S.; Tate, Warren P.
Title: The Highly Conserved Codon following the Slippery Sequence Supports -1 Frameshift Efficiency at the HIV-1 Frameshift Site
  • Document date: 2015_3_25
  • ID: 10p3mth2_50
    Snippet: By contrast, at the natural antizyme intercodon, where there is a weak stop signal (UGAC) eRF1 was a poorer competitor than a UGA suppressor tRNA so frameshifting is high (Fig. 6B) . In terms of an ability to maintain the original frame at the HIV-1 site, the UGA suppressor tRNA fell between relatively inefficient competitors of frameshifting such as the natural tRNA Gly (GGG) and tRNA Trp (UGG), and stronger competitor tRNA Arg isoacceptors (for.....
    Document: By contrast, at the natural antizyme intercodon, where there is a weak stop signal (UGAC) eRF1 was a poorer competitor than a UGA suppressor tRNA so frameshifting is high (Fig. 6B) . In terms of an ability to maintain the original frame at the HIV-1 site, the UGA suppressor tRNA fell between relatively inefficient competitors of frameshifting such as the natural tRNA Gly (GGG) and tRNA Trp (UGG), and stronger competitor tRNA Arg isoacceptors (for AGG/AGA and CGG/CGA).

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