Selected article for: "stable stem and stem upper"
Author: Mathew, Suneeth F.; Crowe-McAuliffe, Caillan; Graves, Ryan; Cardno, Tony S.; McKinney, Cushla; Poole, Elizabeth S.; Tate, Warren P.
Title: The Highly Conserved Codon following the Slippery Sequence Supports -1 Frameshift Efficiency at the HIV-1 Frameshift Site
  • Document date: 2015_3_25
    • ID: 10p3mth2_57
    Snippet: Several reasons suggest caution, however, in direct comparisons of our data with data from these studies. The dnaX and infectious bronchitis virus elements both contain a two-codon spacer between the slippery sequence and the structured RNA element, while the HIV-1 Mtype element contains only a one-base spacer, or alternatively an 8-base spacer if only the more stable upper stem-loop is considered. This may lead to a pause in the case of the elem.....
    Document: Several reasons suggest caution, however, in direct comparisons of our data with data from these studies. The dnaX and infectious bronchitis virus elements both contain a two-codon spacer between the slippery sequence and the structured RNA element, while the HIV-1 Mtype element contains only a one-base spacer, or alternatively an 8-base spacer if only the more stable upper stem-loop is considered. This may lead to a pause in the case of the elements with large spacers, compared with a decrease in translation rate occurring earlier at the HIV-1 element until a more marked pause occurs when the stable upper stem-loop abuts the ribosome [63] . The ribosome has two mechanisms of helicase activity, which may differ with respect to these two downstream structures [65] .

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