Author: Cooray, Samantha; Jin, Li; Best, Jennifer M
Title: The involvement of survival signaling pathways in rubella-virus induced apoptosis Document date: 2005_1_4
ID: 1i36lsj2_21
Snippet: The effect of PI3K and MEK1/2 inhibition on cell viability dur-ing RV infection treatment reduced caspase activity in RV-infected cells by 51.9% (P < 0.05), with a low peak occurring at 48 hours p.i. (Fig. 3A) . The number of dead floating cells in RV and U0126-treated cells was slightly lower than in RV-infected cells at all time points (Fig. 3B) . DNA fragmentation was observed in both RV-infected cells and RV in the presence of U0126 (Fig. 3C).....
Document: The effect of PI3K and MEK1/2 inhibition on cell viability dur-ing RV infection treatment reduced caspase activity in RV-infected cells by 51.9% (P < 0.05), with a low peak occurring at 48 hours p.i. (Fig. 3A) . The number of dead floating cells in RV and U0126-treated cells was slightly lower than in RV-infected cells at all time points (Fig. 3B) . DNA fragmentation was observed in both RV-infected cells and RV in the presence of U0126 (Fig. 3C) , although the presence of the drug also appeared to result in smearing of high molecular weight DNA, characteristic of necrosis [26, 27] . The detrimental effect of U0126 on RK13 cell morphology is shown in Fig. 3D ; this correlates with the rapid decline in cell viability.
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