Author: Hoffmann, Markus; Krüger, Nadine; Zmora, Pawel; Wrensch, Florian; Herrler, Georg; Pöhlmann, Stefan
Title: The Hemagglutinin of Bat-Associated Influenza Viruses Is Activated by TMPRSS2 for pH-Dependent Entry into Bat but Not Human Cells Document date: 2016_3_30
ID: 0ejhd9nw_37
Snippet: Collectively, our results are most compatible with a scenario in which human cells allow for batFLUAV-HAL activation and triggering but fail to express a receptor, which can be employed by HAL for host cell entry. These results, jointly with the documented observation that the batFLUAV replication machinery is functional in human cells [16, 18, 19] suggest that HAL adaptation to a human receptor might be the major hurdle batFLUAV need to overcome.....
Document: Collectively, our results are most compatible with a scenario in which human cells allow for batFLUAV-HAL activation and triggering but fail to express a receptor, which can be employed by HAL for host cell entry. These results, jointly with the documented observation that the batFLUAV replication machinery is functional in human cells [16, 18, 19] suggest that HAL adaptation to a human receptor might be the major hurdle batFLUAV need to overcome to spread in humans. It will thus be highly interesting to identify the nature of this receptor and its interface with batFLUAV-HAL.
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