Author: Lu, Yujie; Liu, Wenjuan; Zhang, Man; Deng, Yanfang; Jiang, Min; Bai, Gang
Title: The Screening Research of NF-?B Inhibitors from Moutan Cortex Based on Bioactivity-Integrated UPLC-Q/TOF-MS Document date: 2019_3_3
ID: 1ahxau9k_25
Snippet: In addition to its anti-inflammatory effects, MC also has cytotoxicity to cancer cells. Recent research has showed that MC extract could reduce cell viability with IC50 within 1∼ 2 mg/ml in bladder cancer cells [7] . And after treatment for 48 h with paeonol (400 g/ml), one of the active ingredients of MC, the ratio of apoptotic cells reached 34.79% [27] . This study demonstrated that, at a concentration of 0.01 mg/mL, the extract of MC already.....
Document: In addition to its anti-inflammatory effects, MC also has cytotoxicity to cancer cells. Recent research has showed that MC extract could reduce cell viability with IC50 within 1∼ 2 mg/ml in bladder cancer cells [7] . And after treatment for 48 h with paeonol (400 g/ml), one of the active ingredients of MC, the ratio of apoptotic cells reached 34.79% [27] . This study demonstrated that, at a concentration of 0.01 mg/mL, the extract of MC already had anti-inflammatory activity. Taking paeonol as an example, it showed significant NF-B inhibitory effects at a concentration of 10 −5 mol/L, which was much lower than its toxic content. This finding was in agreement with the characterization of most drugs as playing a therapeutic role in a certain dose range.
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