Author: Joshi, Shilvi; Chen, Lang; Winter, Michael B.; Lin, Yi-Lun; Yang, Yang; Shapovalova, Mariya; Smith, Paige M.; Liu, Chang; Li, Fang; LeBeau, Aaron M.
Title: The Rational Design of Therapeutic Peptides for Aminopeptidase N using a Substrate-Based Approach Document date: 2017_5_2
ID: 0pmo3opx_27
Snippet: The six amino acids were soaked into pAPN crystals to determine the structures of the pAPN/amino acid complexes. The structure of the unliganded pAPN was used to determine the structures of amino acid-soaked pAPN. Objective Fo-Fc omit maps were calculated in the absence of amino acids and showed strong electron density for each of the amino acids (Supplemental Figure 4) . Based on these maps, the models of amino acids were built, and the models o.....
Document: The six amino acids were soaked into pAPN crystals to determine the structures of the pAPN/amino acid complexes. The structure of the unliganded pAPN was used to determine the structures of amino acid-soaked pAPN. Objective Fo-Fc omit maps were calculated in the absence of amino acids and showed strong electron density for each of the amino acids (Supplemental Figure 4) . Based on these maps, the models of amino acids were built, and the models of pAPN/amino acid complexes were further refined. Crystallographic statistics can be found in Supplemental Figure 5 .
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