Author: Grabiec, Aleksander M.; Hussell, Tracy
Title: The role of airway macrophages in apoptotic cell clearance following acute and chronic lung inflammation Document date: 2016_3_8
ID: 1f47gvys_38
Snippet: The antimicrobial role of apoptotic cell clearance in pulmonary infections is not restricted to bacteria as the influenza A virus induces apoptosis of epithelial cells upon infection and engulfment of influenza A-infected cells by macrophages is associated with reduction of viral titres [124] . On the other hand, infection of macrophages with Francisella novicida, a member of the Francisellaceae family of intracellular bacteria which cause pulmon.....
Document: The antimicrobial role of apoptotic cell clearance in pulmonary infections is not restricted to bacteria as the influenza A virus induces apoptosis of epithelial cells upon infection and engulfment of influenza A-infected cells by macrophages is associated with reduction of viral titres [124] . On the other hand, infection of macrophages with Francisella novicida, a member of the Francisellaceae family of intracellular bacteria which cause pulmonary inflammation associated with necrotic infiltrates in the lung, reduces their efferocytic function, potentially contributing to the accumulation of necrotic cell debris and exacerbation of disease [125] .
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