Author: Law, Helen KW; Cheung, Chung Yan; Sia, Sin Fun; Chan, Yuk On; Peiris, JS Malik; Lau, Yu Lung
Title: Toll-like receptors, chemokine receptors and death receptor ligands responses in SARS coronavirus infected human monocyte derived dendritic cells Document date: 2009_6_8
ID: 19noki6p_23
Snippet: Among the CCRs studied, the upregulation of CCR-3 is the strongest (Fig. 3) . It has been reported that the expression of CCR-3, unlike CCR-5 and CCR-7, are independent of the maturation status of DCs [13, 14] . Further investigation is needed to determine which mechanism is involved in CCR-3 upregulation. In addition to cell trafficking, CCR-3 has also been reported to function as a death receptor on B cells [30] . Whether CCR-3 expression is re.....
Document: Among the CCRs studied, the upregulation of CCR-3 is the strongest (Fig. 3) . It has been reported that the expression of CCR-3, unlike CCR-5 and CCR-7, are independent of the maturation status of DCs [13, 14] . Further investigation is needed to determine which mechanism is involved in CCR-3 upregulation. In addition to cell trafficking, CCR-3 has also been reported to function as a death receptor on B cells [30] . Whether CCR-3 expression is related to the characteristic antibody responses in SARS and the alternative function of CCRs on SARS-CoV infected DCs will need to be explored further.
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