Author: Shapira, Assaf; Benhar, Itai
Title: Toxin-Based Therapeutic Approaches Document date: 2010_10_28
ID: 00cf294x_31
Snippet: In another study, a nanoparticulate system based on the cationic poly(b-amino ester)polymer, C32 [375] , was used as a DNA delivery system of a suicide gene encoding for a diphtheria toxin A chain (DT-A) under the transcriptional regulation of a prostate-specific modified human PSA promoter, PSE-BC [371] . The genetic material/cationic polymer complex was locally delivered into normal prostate and prostate tumors in mice, causing massive apoptoti.....
Document: In another study, a nanoparticulate system based on the cationic poly(b-amino ester)polymer, C32 [375] , was used as a DNA delivery system of a suicide gene encoding for a diphtheria toxin A chain (DT-A) under the transcriptional regulation of a prostate-specific modified human PSA promoter, PSE-BC [371] . The genetic material/cationic polymer complex was locally delivered into normal prostate and prostate tumors in mice, causing massive apoptotic prostate cell death, without damaging surrounding tissue [341] .
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