Author: Neufeldt, Christopher J.; Joyce, Michael A.; Van Buuren, Nicholas; Levin, Aviad; Kirkegaard, Karla; Gale Jr., Michael; Tyrrell, D. Lorne J.; Wozniak, Richard W.
Title: The Hepatitis C Virus-Induced Membranous Web and Associated Nuclear Transport Machinery Limit Access of Pattern Recognition Receptors to Viral Replication Sites Document date: 2016_2_10
ID: 1kuggdzj_8
Snippet: In this study, we have investigated the organization of the MW and further evaluated the role of the nuclear transport machinery in the formation of a selective barrier between the viral replication/assembly complexes and the cytosol. We present data supporting a role for virusinduced cytoplasmic compartments in concealing viral PAMPs from RLR recognition in the cytoplasm of cells infected with positive-strand RNA viruses. We also provide evidenc.....
Document: In this study, we have investigated the organization of the MW and further evaluated the role of the nuclear transport machinery in the formation of a selective barrier between the viral replication/assembly complexes and the cytosol. We present data supporting a role for virusinduced cytoplasmic compartments in concealing viral PAMPs from RLR recognition in the cytoplasm of cells infected with positive-strand RNA viruses. We also provide evidence for the formation of distinct replication and assembly compartments within the MW, and we describe a useful technique for isolating these compartments. Furthermore, we present data indicating the nuclear transport machinery contributes to the selective movement of molecules into the MW and the exclusion of cytoplasmic RLRs.
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