Author: Brandon Alexander Holt; Gabriel A. Kwong
Title: Bacterial defiance as a form of prodrug failure Document date: 2019_2_21
ID: 9le4s67m_3
Snippet: While AMP prodrugs eliminate the majority of bacteria, we observe bacteria populations exhibiting a phenotype we named "defiant", proliferating in the presence of active drug by consistently outpacing prodrug activation at all stages of growth (i.e., log phase, stationary phase)......
Document: While AMP prodrugs eliminate the majority of bacteria, we observe bacteria populations exhibiting a phenotype we named "defiant", proliferating in the presence of active drug by consistently outpacing prodrug activation at all stages of growth (i.e., log phase, stationary phase).
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