Author: Tan, Jinzhi; Vonrhein, Clemens; Smart, Oliver S.; Bricogne, Gerard; Bollati, Michela; Kusov, Yuri; Hansen, Guido; Mesters, Jeroen R.; Schmidt, Christian L.; Hilgenfeld, Rolf
Title: The SARS-Unique Domain (SUD) of SARS Coronavirus Contains Two Macrodomains That Bind G-Quadruplexes Document date: 2009_5_15
ID: 1aqt65cc_12
Snippet: The fold of each SUD subdomain is that of a macrodomain ( Figure 2A) . Macrodomains consist of a largely parallel central bsheet surrounded by 4-6 a-helices. The order of regular secondary-structure elements in SUD-N is bN1-aN1-bN2-aN2-bN3-bN4-aN3-bN5-aN4-bN6, and in SUD-M bM1-aM1-bM2-aM2-bM3-bM4-aM3-bM5-aM4-bM6-aM5. The topology of the b-strands is b1-b6-b5-b2-b4-b3, all of which are parallel except b3 (Figure 2A ). Between the two subdomains, m.....
Document: The fold of each SUD subdomain is that of a macrodomain ( Figure 2A) . Macrodomains consist of a largely parallel central bsheet surrounded by 4-6 a-helices. The order of regular secondary-structure elements in SUD-N is bN1-aN1-bN2-aN2-bN3-bN4-aN3-bN5-aN4-bN6, and in SUD-M bM1-aM1-bM2-aM2-bM3-bM4-aM3-bM5-aM4-bM6-aM5. The topology of the b-strands is b1-b6-b5-b2-b4-b3, all of which are parallel except b3 (Figure 2A ). Between the two subdomains, most of the secondary-structure elements are conserved with respect to their position in the three-dimensional structure, although they often differ in length. This is particularly obvious for a-helix 1, which comprises just four residues in the N-terminal subdomain but eleven in the M subdomain. Similarly, a-helix 2 has 5 vs. 10 amino-acid residues in the two subdomains. In general, the strands of the central b-sheet appear to align better between the two subdomains than do the a-helices.
Search related documents:
Co phrase search for related documents- amino acid and helix subdomain: 1
- amino acid and length differ: 1, 2
- amino acid and secondary structure: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75
- amino acid and secondary structure element: 1
- amino acid and SUD subdomain: 1, 2
- amino acid residue and secondary structure: 1, 2, 3
- better align and secondary structure: 1
Co phrase search for related documents, hyperlinks ordered by date