Author: Zapata, Juan Carlos; Carrion, Ricardo; Patterson, Jean L.; Crasta, Oswald; Zhang, Yan; Mani, Sachin; Jett, Marti; Poonia, Bhawna; Djavani, Mahmoud; White, David M.; Lukashevich, Igor S.; Salvato, Maria S.
Title: Transcriptome Analysis of Human Peripheral Blood Mononuclear Cells Exposed to Lassa Virus and to the Attenuated Mopeia/Lassa Reassortant 29 (ML29), a Vaccine Candidate Document date: 2013_9_12
ID: 0epeljaf_31
Snippet: In a previous transcriptome profiling study using a surrogate LF model in monkeys we showed that significant changes in PBMC gene expression occurred during pre-viremic days 1, 2, and 3 [24] , clearly differentiating pathogenic versus non-pathogenic infections even before detectable virus replication. Clearly, a large part of the response to viruses is due to signal transduction of uninfected bystander cells......
Document: In a previous transcriptome profiling study using a surrogate LF model in monkeys we showed that significant changes in PBMC gene expression occurred during pre-viremic days 1, 2, and 3 [24] , clearly differentiating pathogenic versus non-pathogenic infections even before detectable virus replication. Clearly, a large part of the response to viruses is due to signal transduction of uninfected bystander cells.
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