Author: Tan, Jinzhi; Vonrhein, Clemens; Smart, Oliver S.; Bricogne, Gerard; Bollati, Michela; Kusov, Yuri; Hansen, Guido; Mesters, Jeroen R.; Schmidt, Christian L.; Hilgenfeld, Rolf
Title: The SARS-Unique Domain (SUD) of SARS Coronavirus Contains Two Macrodomains That Bind G-Quadruplexes Document date: 2009_5_15
ID: 1aqt65cc_13
Snippet: Each of the SUD core subdomains is related to the macrodomain of the histone macro2A ( [18] ; PDB code 1ZR3, molecule C; for SUD-N: Z-score 9.8, r.m.s.d. 2.5 Ã… for 112 out of 184 Ca atoms, 12% sequence identity; for SUD-M: Z-score 8.6, r.m.s.d. 2.8 Ã… for 115 out of 184 Ca atoms, 19% sequence identity). Called ''Xdomains'', single macrodomains are also found in alphaviruses, in hepatitis E virus, and in rubella virus, in addition to coronaviruse.....
Document: Each of the SUD core subdomains is related to the macrodomain of the histone macro2A ( [18] ; PDB code 1ZR3, molecule C; for SUD-N: Z-score 9.8, r.m.s.d. 2.5 Ã… for 112 out of 184 Ca atoms, 12% sequence identity; for SUD-M: Z-score 8.6, r.m.s.d. 2.8 Ã… for 115 out of 184 Ca atoms, 19% sequence identity). Called ''Xdomains'', single macrodomains are also found in alphaviruses, in hepatitis E virus, and in rubella virus, in addition to coronaviruses [27, 28] . The SARS-CoV X-domain (Nsp3b), the domain immediately preceding the SUD in Nsp3, shares no recognizable sequence identity with SUD-N (12%) or SUD-M (7%) ( Figure 2C ), but its three-dimensional structure [22, 23] (PDB code 2ACF, chain A) can be superimposed onto each of the two SUD subdomains with an r.m.s.d. (based on Ca atoms) of 2.7 Ã… and 2.3 Ã… , respectively ( Figure 2D ). Thus, within Nsp3, SARS-CoV has three macrodomains aligned one after the other.
Search related documents:
Co phrase search for related documents- core subdomain and sequence identity: 1, 2
- core subdomain and SUD core subdomain: 1, 2
- core subdomain and SUD subdomain: 1, 2
- dimensional structure and PDB code: 1
- dimensional structure and SARS cov: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73
- dimensional structure and sequence identity: 1, 2, 3, 4, 5, 6, 7, 8
- dimensional structure and SUD subdomain: 1
- PDB code and SARS cov: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- PDB code and sequence identity: 1, 2
- PDB code and SUD subdomain: 1
- rubella virus and SARS cov: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17
- rubella virus and sequence identity: 1, 2, 3
- SARS cov and sequence identity: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85
- SARS cov and SUD core subdomain: 1
- SARS cov and SUD subdomain: 1, 2, 3, 4
- sequence identity and SUD core subdomain: 1, 2
- sequence identity and SUD subdomain: 1, 2
Co phrase search for related documents, hyperlinks ordered by date