Selected article for: "activate protein and vector control"
Author: Qian, Shaoju; Gao, Zitong; Cao, Rui; Yang, Kang; Cui, Yijie; Li, Shaowen; Meng, Xianrong; He, Qigai; Li, Zili
Title: Transmissible Gastroenteritis Virus Infection Up-Regulates FcRn Expression via Nucleocapsid Protein and Secretion of TGF-ß in Porcine Intestinal Epithelial Cells
  • Document date: 2020_1_21
    • ID: 06qddkw0_31
    Snippet: In this study, we used confocal microscopy to identify that the TGEV N protein has an effect on the nuclear translocation of the NF-κB subunit p65. We observed the control vector-transfected IPEC-J2 cells and p65-EGFP was mainly present in the cytoplasm. Interestingly, the overexpression of TGEV N could lead to p65-EGFP expression in the nucleus in transfected IPEC-J2 cells ( Figure 4G) . Taken together, these results demonstrated that TGEV N pr.....
    Document: In this study, we used confocal microscopy to identify that the TGEV N protein has an effect on the nuclear translocation of the NF-κB subunit p65. We observed the control vector-transfected IPEC-J2 cells and p65-EGFP was mainly present in the cytoplasm. Interestingly, the overexpression of TGEV N could lead to p65-EGFP expression in the nucleus in transfected IPEC-J2 cells ( Figure 4G) . Taken together, these results demonstrated that TGEV N protein can both significantly activate NF-κB and upregulate the expression of FcRn.

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